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The Neelakantan 2018 study in Biochemical Pharmacology reported that 5-Amino-1MQ administration to C57BL/6 mice on a 60% kcal-from-fat high-fat diet produced concentration-dependent reductions in fat mass and adipose-tissue NNMT enzymatic activity without significant changes in lean mass or food intake [1]

Maintenance phase: Once the loading phase is complete, patients transition to maintenance therapy with 1 mg hydroxocobalamin intramuscularly every two to three months for life

(2017) "Design and synthesis of NNMT inhibitors with tunable cell permeability." Published in Journal of Medicinal Chemistry

Both molecules have real signal